Table 1.
Comparison of MMPs and TIMPs between HIIT and CON groups.
| Variable | Baseline, mean (SD) | Post-intervention | Between Group Difference Post intervention | ||
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | P | Mean (95% CI) | P | |
| MMP-1 (ng/ml) | 4.5 (−2.1 to 11.1) | 0.98 | |||
| HIIT | 14.9 (11.7) | 19.4 (12.4) | 0.17 | ||
| CON | 14.3 (19.2) | 18.8 (21.6) | 0.14 | ||
| MMP-2 (ng/ml) | 6.5 (2.1 to 10.9) | 0.53 | |||
| HIIT | 76.6 (11.2) | 83.2 (13.1) | 0.007* | ||
| CON | 69.0 (8.9) | 77.6 (11.1) | 0.003* | ||
| MMP-7 (ng/ml) | −0.05 (−0.64 to 0.54) | 0.33 | |||
| HIIT | 4.4 (0.9) | 4.3 (0.8) | 0.85 | ||
| CON | 4.8 (2.6) | 4.3 (2.7) | 0.13 | ||
| MMP-9 (ng/ml) | −46.4 (−80.4 to 12.4) | 0.65 | |||
| HIIT | 104.3 (51.9) | 65.2 (69.1) | 0.01* | ||
| CON | 115.5 (47.2) | 90.4 (67.9) | 0.10 | ||
| MMP-10 (ng/ml) | 0.02 (−0.4 to 0.5) | 0.61 | |||
| HIIT | 1.4 (0.7) | 1.4 (0.5) | 0.91 | ||
| CON | 1.7 (1.4) | 1.5 (0.9) | 0.62 | ||
| TIMP-1 (ng/ml) | 15.3 (−54.4 to 84.9) | 0.67 | |||
| HIIT | 362.2 (92.5) | 377.5 (91.5) | 0.65 | ||
| CON | 322.3 (92.6) | 354.3 (87.3) | 0.17 | ||
| TIMP-2 (ng/ml) | 0.4 (−7.2 to 7.9) | 0.46 | |||
| HIIT | 93.3 (12.6) | 93.7 (12.1) | 0.92 | ||
| CON | 86.3 (10.9) | 89.8 (14.5) | 0.11 | ||
HIIT, high intensity interval training; CON, control; MMP, matrix metalloproteinases, TIMP, tissue inhibitor of matrix metalloproteinases.
*P value denotes significant change in outcome measure at the p < 0.05 level by paired t-test comparing changes in the HIIT group from baseline to post-intervention, and in the CON group from baseline to post-intervention.