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. 2020 Apr 3;10:5889. doi: 10.1038/s41598-020-62039-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of ^195mPt-BP and ^195mPt(NO₃)₂(en) biodistribution in vivo. (A) Percentage of injected dose (%ID/g) of ^195mPt-BP (after 7 days) and ^195mPt(NO₃)₂(en) (after 3 days) in mice determined using gamma counting. (B) Percentage of injected dose (%ID/g) of ^195mPt-BP and ^195mPt(NO₃)₂(en) in mice as quantified from the micro-SPECT/CT images in soft and hard tissues. (C) Percentage of injected dose (%ID/g) of ^195mPt-BP and ^195mPt(NO₃)₂(en) in mice as quantified from the micro-SPECT/CT images in the hard tissue region of interest (ROI) with the location of the edge of the ROI contour representing 75% of maximum intensity. (D) ^195mPt hard-to-soft tissue uptake ratio excluding bladder uptake at 1 h. Data from 4–5 mice per group are presented. **P < 0.01; ****P < 0.0001 as determined by two-way ANOVA with a Bonferroni (multiple comparisons) post-hoc test. For the ratios, paired t-test was used to determine the differences among the two groups where **P < 0.01 was considered as significantly different.