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. 2020 Apr 3;10:5910. doi: 10.1038/s41598-020-62474-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Specificity of the C6Mα3 assay. C6Mα3 fragments after 24 h in vitro incubation of human collagen type VI (COL6), with MMP-2 (COL6 + MMP-2) and MMP-9 (COL6 + MMP-9). The negative controls were the enzymes (MMP-2 and MMP-9) without COL6 and the intact COL6 without enzymes. Results are corrected for background.