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. 2020 Apr 3;10:5923. doi: 10.1038/s41598-020-62293-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo mouse xenograft study (A–C) with radiosensitive HCT116 and (D,E) radioresistant A431 tumors. (A) HCT116 tumor growth over time (n > 6 per group, error bars = SD). HCT116 xenografts followed over time, until the first animal in each group was sacrificed. (B) HCT116 tumor size on day 7 (one week after treatment start). (C) Survival proportions of the different treatment groups. Statistical significance *P = 0.05, n > 6, error bars = SD. (D) A431 tumor growth over time (n > 4 per group, error bars = SD). A431 xenografts followed over time, until the first animal in each group was sacrificed. (E) A431 tumor size on day 7 (one week after treatment start). (F) Synergistic effects displayed as combination index (CI) plot for the combination of Onalespib and radiotherapy treated HCT116 and A431 tumor xenografts (CI < 0.8).