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. 2020 Apr 3;10:5891. doi: 10.1038/s41598-020-62691-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Therapeutic effect of vB_KpnS_Kp13 in an intraperitoneal (IP) mouse infection model. Phage administration occurred 10 min (P 10 min, blue, ♦), 1 hour (P 1 h, red, ■) and 3 hours (P 3 h, green, ▲) post-infection, while the K. pneumoniae 533 (K. pn. 533, purple, ×) and the phage vB_KpnS_Kp13 (only P, pink, ●) suspensions were used as positive and negative controls, respectively. The graphs show percent survival of mice from the start of IP infection over 240 h. Each data point is the mean from two experiments (altogether 8 mice in one group). Error bars represent standard deviation. For better visibility we artificially lowered the values of the phage control (only P, pink, ●) from 100% to 97%.