Table 3.

Inter-observer and intra-observer reproducibility for GLS, GCS and GRS

	Parameter	Steps	Mean difference ± SD	Limits of agreement	ICC (95% CI)
Inter-observer variability	GLS	BL	− 1.0 ± 3.0	− 6.9 to 4.8	0.88 (0.57–0.97)
		Dob	− 4.5 ± 10.0	− 24.1 to 15.1	0.60 (− 0.35 to 0.89)
		Ver	3.5 ± 4.2	− 4.7 to 11.7	0.79 (0.10–0.95)
	GCS	BL	− 2.2 ± 7.6	− 17.2 to 12.6	0.66 (− 0.21 to 0.92)
		Dob	− 0.4 ± 11.5	− 23.0 to 22.2	0.51 (− 0.23 to 0.87)
		Ver	2.4 ± 3.4	− 4.3 to 9.2	0.61 (− 0.40 to 0.90)
	GRS	BL	21.7 ± 11.6	− 0.9 to 44.5	0.80 (0.21–0.95)
		Dob	1.2 ± 29.6	− 56.9 to 59.3	− 1.60 (− 9.47 to 0.35)
		Ver	24.7 ± 12.6	0.1 to 49.4	0.24 (− 2.03 to 0.81)
Intra-observer variability	GLS	BL	2.8 ± 2.9	− 2.8 to 8.5	0.81 (0.41–0.95)
		Dob	− 0.4 ± 7.3	− 14.8 to 14.0	0.87 (0.45–0.96)
		Ver	4.3 ± 4.3	− 4.1 to 12.7	0.75 (0.01–0.94)
	GCS	BL	1.7 ± 1.5	− 1.3 to 4.7	0.98 (0.77–0.99)
		Dob	1.8 ± 3.4	− 4.8 to 8.4	0.97 (0.89–0.99)
		Ver	1.6 ± 1.4	− 1.1 to 4.4	0.95 (0.36–0.99)
	GRS	BL	− 1.5 ± 12.7	− 26.4 to 23.3	0.79 (0.15–0.94)
		Dob	− 15.1 ± 31.1	− 76.0 to 45.8	0.62 (− 0.50 to 0.90)
		Ver	− 23.6 ± 15.7	− 54.4 to 7.2	0.14 (− 2.43 to 0.78)

Results are reported as mean ± standard deviation

BL baseline, CI confidence interval, Dob Dobutamine, GCS global circumferential strain, GLS global longitudinal strain, GRS global radial strain, ICC intra-class correlation coefficient, Ver Verapamil