Table 3.
Logistic regression analysis of the associations of demographic and clinical variables with pregnancy outcomes after PGT-A in 709 couples with prior pregnancy failures
| Variables | Implantation | Early miscarriage | Live birth | ||||||
|---|---|---|---|---|---|---|---|---|---|
| P | aOR | 95%CI | P | aOR | 95%CI | P | aOR | 95%CI | |
| Age | 0.09 | 0.95 | 0.90–1.01 | 0.17 | 0.95 | 0.88–1.02 | 0.34 | 0.98 | 0.93–1.03 |
| BMI | 0.38 | 1.02 | 0.97–1.08 | 0.07 | 1.07 | 0.99–1.14 | 0.90 | 1.00 | 0.96–1.05 |
| AMH | 0.03* | 1.06 | 1.01–1.13 | 0.81 | 0.99 | 0.92–1.06 | 0.07 | 1.05 | 0.99–1.10 |
| Ovarian stimulation protocols | |||||||||
| Long | – | ||||||||
| Antagonist | 0.82 | 0.94 | 0.54–1.63 | 0.54 | 1.26 | 0.59–2.70 | 0.50 | 0.84 | 0.51–1.38 |
| Short | 0.96 | 0.99 | 0.65–1.52 | 0.93 | 0.97 | 0.51–1.85 | 0.67 | 0.92 | 0.62–1.36 |
| Ultra-long | 0.68 | 0.82 | 0.32–2.11 | 0.67 | 0.71 | 0.15–3.46 | 0.65 | 0.82 | 0.34–1.96 |
| Others | 0.26 | 0.51 | 0.16–1.64 | 0.91 | 0.88 | 0.10–7.55 | 0.29 | 0.54 | 0.17–1.7 |
| Prior live birth | 0.71 | 1.10 | 0.68–1.79 | 0.42 | 1.33 | 0.67–2.68 | 0.62 | 1.12 | 0.72–1.76 |
| IF | |||||||||
| ≤ 2 | – | ||||||||
| 3 | 0.23 | 0.66 | 0.34–1.30 | 0.70 | 0.74 | 0.16–3.47 | 0.62 | 0.85 | 0.44–1.64 |
| 4 | 0.54 | 1.30 | 0.56–3.01 | 0.19 | 2.27 | 0.66–7.76 | 0.62 | 0.83 | 0.40–1.73 |
| ≥ 5 | 0.65 | 0.82 | 0.36–1.90 | 0.09 | 2.99 | 0.84–10.73 | 0.28 | 0.65 | 0.30–1.42 |
| BPL | |||||||||
| ≤ 1 | – | ||||||||
| 2–3 | 0.55 | 0.83 | 0.45–1.53 | 0.37 | 1.58 | 0.59–4.25 | 0.32 | 0.75 | 0.43–1.32 |
| ≥ 4 | 0.83 | 1.14 | 0.35–3.67 | 0.35 | 2.17 | 0.43–10.92 | 0.53 | 0.72 | 0.27–1.97 |
| EM | |||||||||
| ≤ 1 | – | ||||||||
| 2 | 0.91 | 1.03 | 0.60–1.77 | 0.22 | 1.72 | 0.725–4.1 | 0.65 | 0.89 | 0.55–1.46 |
| 3 | 0.91 | 1.04 | 0.54–2.00 | 0.07 | 2.51 | 0.95–6.64 | 0.29 | 0.73 | 0.41–1.31 |
| ≥ 4 | 0.69 | 1.18 | 0.51–2.74 | 0.001* | 6.49 | 2.17–19.46 | 0.120 | 0.56 | 0.26–1.17 |
| Prior LM | 0.90 | 1.05 | 0.51–2.18 | 0.007* | 3.16 | 1.36–7.35 | 0.024* | 0.48 | 0.25–0.91 |
| No. of prior intrauterine operations | |||||||||
| ≤ 1 | – | ||||||||
| 2 | 0.49 | 1.19 | 0.73–1.95 | 0.55 | 1.24 | 0.62–2.50 | 0.58 | 1.13 | 0.73–1.76 |
| 3 | 0.90 | 1.04 | 0.54–2.02 | 0.68 | 0.82 | 0.32–2.13 | 0.79 | 1.08 | 0.60–1.95 |
| ≥ 4 | 0.06 | 0.50 | 0.25–1.01 | 0.73 | 0.85 | 0.33–2.18 | 0.038* | 0.51 | 0.27–0.96 |
IF implantation failure, BPL biochemical pregnancy loss, EM early miscarriage, LM late miscarriage, aOR adjusted odds ratio
*Significant difference