Fig. 5.

Probability distribution across the lipid bilayer. Probability distribution functions across the lipid bilayer for different component groups of lipids (CH₃, methyl group, red; PO₄, phosphate group, orange), different domains of KRas4B (catalytic domain, yellow; HVR, green; farnesyl, blue), and different domains of Raf-1 (RBD, dark blue; CRD, purple) as a function of distance from the bilayer center, d, for four different TCs (1–4) of quaternary KRas4B–Raf-1 complex at the anionic bilayer composed of DOPC:DOPS (molar ratio 4:1). The first (KRas4B^M1/Raf-1^M1) and the second (KRas4B^M2/Raf-1^M2) monomeric units are separately shown in each TC. The arrows at d = ~ 20 Å denote the bilayer surface at z = 0. Color code denotes different colors used for the domains of KRas4B, Raf-1, and lipid groups as in the schematic diagram of the quaternary complex. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)