Table 1.
The 42 residues positions in BRCT and the corresponding VUS.
| Amino acid position | Amino acid | Codon | VUS altering phosphopeptide binding with BACH1 |
|---|---|---|---|
| 1647 | N | AAT | 1 (K) |
| 1651 | S | TCA | 1 (P) |
| 1652 | M | ATG | 1 (T) |
| 1655 | S | TCA | 6 (T,P,A,Y,C,F) |
| 1656 | G | GGA | 6 (R,C,S,V,A,D) |
| 1661 | E | GAA | 1 (K) |
| 1662 | F | TTC | 1 (S) |
| 1663 | M | ATG | 1 (K) |
| 1665 | V | GTG | 5 (M,L,G,A,E) |
| 1669 | A | GCT | 5 (T,S,P,G,D) |
| 1686 | H | CAC | 1 (R) |
| 1689 | M | ATG | 2 (R, T) |
| 1690 | K | AAG | 1 (Q) |
| 1691 | T | ACG | 1 (A, I) |
| 1692 | D | GAC | 7 (N,Y,H,G,A,V,E) |
| 1697 | C | TGC | 1 (Y) |
| 1699 | R | AGA | 3 (G,P,L) |
| 1701 | L | CTG | 1 (M) |
| 1702 | K | AAG | 6 (E,Q,I,T,R,N) |
| 1704 | F | TTC | 6 (V,L,I,S,C,Y) |
| 1706 | G | GGA | 1 (E) |
| 1708 | A | GCT | 1 (V) |
| 1715 | S | TCA | 7 (C,R,G,N,I,T,R) |
| 1716 | Y | TAC | 1 (C) |
| 1718 | W | TGG | 5 (G,R,L,S,C) |
| 1720 | T | ACG | 2 (S,A) |
| 1723 | I | ATT | 1 (N) |
| 1724 | K | AAG | 1 (N) |
| 1729 | L | CTG | 1 (Q) |
| 1738 | G | GGA | 6 (R,G,R,E,A,V) |
| 1739 | D | GAC | 7 (H,N,Y,A,V,G,E) |
| 1748 | G | GGA | 1 (C) |
| 1749 | P | CCA | 6 (T,S,A,L,Q,R) |
| 1751 | R | AGA | 4 (G,P,Q,L) |
| 1752 | A | GCT | 6 (S,P,T,V,E,G) |
| 1763 | G | GGA | 1 (V) |
| 1766 | I | ATT | 1 (V) |
| 1775 | M | ATG | 6 (L,V,R,T,W,I) |
| 1783 | M | ATG | 6 (L,V,K,R,T,I) |
| 1809 | V | GTG | 3 (I,D,A) |
| 1839 | L | CTG | 2 (S,F) |
| 1853 | Y | TAC | 4 (D,N,H,F) |
| Total | 131 |