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. 2020 Mar 30;15:2171–2195. doi: 10.2147/IJN.S246601

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© 2020 Aman et al.

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Photomicrographs of histopathological evaluation of the anti-inflammatory activity of the investigated formulae.

Notes: (A) normal control group, (B) croton oil-treated group, (C) pure CEO group (once application), (D) CEO-NE-based NEG (once application), (E) plain-NE-based NEG (twice application), (F) CEO-NE-based NEG (twice application), (G) plain-NE-based NFs (once application), and (H) CEO-NE-based NFs (once application). Thick black arrow points to epidermal damage with marked PMN cells infiltration, thin red arrow points to PMN cells infiltration in dermis, and thin black arrow points to congested blood vessel. H&E, X: 100 bar: 100 µm.

Abbreviations: CEO, clove essential oil; H&E, hematoxylin and eosin; NE, nanoemulsion; NEG, nanoemulgel; NFs, nanofibers; PMN, polymorphonuclear cells.