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. 2020 Mar 30;15:2171–2195. doi: 10.2147/IJN.S246601

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© 2020 Aman et al.

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Photomicrographs of IHC evaluation of COX-2 expression level of the investigated formulae.

Notes: (A) normal control group, (B) croton oil-treated group, (C) pure CEO group (once application), (D) CEO-NE-based NEG (once application), (E) plain-NE-based NEG (twice application), (F) CEO-NE-based NEG (twice application), (G) plain-NE-based NFs (once application), and (H) CEO-NE-based NFs (once application). Thick black arrow points to positively stained PMN cells infiltration in epidermis, and thin black arrows point to positively stained PMN cells infiltration in dermis. IHC counterstained with Mayer’s hematoxylin, X: 100 bar: 100 µm.

Abbreviations: CEO, clove essential oil; COX-2, cyclooxygenase-2; IHC, immunohistochemical; NE, nanoemulsion; NEG, nanoemulgel; NFs, nanofibers; PMN, polymorphonuclear cells.