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. 2020 Mar 30;15:2171–2195. doi: 10.2147/IJN.S246601

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© 2020 Aman et al.

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Photomicrographs of histopathological evaluation of skin irritation test.

Notes: (A) normal control mice, (B) formalin treated mice, (C) CEO-NE-based NEG (twice application), and (D) CEO-NE-based NFs (once application). Thin red arrow points to PMN cells infiltration in dermis and thin black arrow points to congested blood vessel. H&E, X: 100 bar: 100 µm.

Abbreviations: CEO, clove essential oil; H&E, hematoxylin and eosin; NE, nanoemulsion; NEG, nanoemulgel; NFs, nanofibers; PMN, polymorphonuclear cells.