Table 2.

Cox regression analysis for the predictors of a clinical recurrence of AF after AFCA.

	Univariable analysis		Multivariable model 1*		Multivariable model 2†
	Unadjusted HR (95% CI)	p value	Adjusted HR (95%CI)	p value	Adjusted HR (95% CI)	p value
Age	1.00 (0.99–1.01)	0.722	0.99 (0.99–1.00)	0.104	0.99 (0.99–1.00)	0.061
BMI	1.01 (0.99–1.04)	0.227	1.00 (0.98–1.03)	0.864	1.00 (0.98–1.03)	0.753
Female	1.13 (0.97–1.30)	0.114	1.17 (1.00–1.36)	0.047	1.02 (0.86–1.21)	0.800
Paroxysmal AF	0.57 (0.50–0.66)	<0.001	0.69 (0.58–0.82)	<0.001	0.67 (0.57–0.80)	<0.001
Warfarin vs. NOAC	1.19 (1.03–1.39)	0.020	1.10 (0.94–1.28)	0.240	1.09 (0.94–1.28)	0.263
Smoking (vs. Never)
Former	0.93 (0.80–1.09)	0.374
Current	1.07 (0.86–1.34)	0.555
Alcohol (vs. Never)
Former	0.90 (0.75–1.07)	0.239
Current	0.90 (0.78–1.05)	0.197
Hypertension	1.03 (0.90–1.17)	0.695
Diabetes	1.04 (0.87–1.25)	0.659
Prior stroke/TIA	1.15 (0.94–1.40)	0.167
Vascular disease	1.02 (0.84–1.25)	0.812
CHA2DS2-VASc score	1.03 (0.99–1.07)	0.170
LA diameter	1.04 (1.03–1.05)	<0.001	1.03 (1.01–1.04)	<0.001	1.03 (1.01–1.04)	0.001
LVEF	0.99 (0.99–1.00)	0.102
Extra-PV LA ablation	1.55 (1.36–1.77)	<0.001	1.17 (0.98–1.38)	0.076	1.16 (0.97–1.37)	0.098
CTI ablation	0.87 (0.69–1.09)	0.221
Baseline eGFR	1.00 (0.99–1.00)	0.722
Baseline hemoglobin	0.93 (0.89–0.97)	0.001			0.90 (0.86–0.95)	<0.001
Baseline RDW	1.09 (1.02–1.16)	0.014	1.01 (0.94–1.09)	0.804	1.00 (0.93–1.08)	0.913
Baseline anemia	1.41 (1.16–1.72)	0.001	1.45 (1.17–1.80)	0.001

CI = confidence interval, HR = Hazard ratio. The other abbreviations are defined in Table 1.

Abbreviations: PV, pulmonary vein; CTI, cavo-tricuspid isthmus.

^*Model 1; Adjusted for the age, BMI, sex, AF types, anticoagulation, LA diameter, Extra-PV LA ablation, CTI ablation, baseline RDW, and anemia.

^†Model 2; Adjusted for the age, BMI, sex, AF types, anticoagulation, LA diameter, Extra-PV LA ablation, CTI ablation, baseline RDW, and haemoglobin.