Table 2.
Effect of MPGL on serum and urine parameters in gentamicin-induced nephropathy (Mean ± SEM).
| Groups | Serum albumin (gm%) | Urine albumin (gm/ml/24 h) | BUN (mg/dl) | Serum creatinine (mg/dl) | Urine creatinine (mg/ml/24 h) |
|---|---|---|---|---|---|
| Normal control | 5.574 ± 1.156 | 0.036 ± 0.002 | 13.173 ± 0.959 | 0.915 ± 0.156 | 20.596 ± 2.686 |
| Negative control | 1.548 ± 0.246### | 1.274 ± 0.037### | 53.173 ± 5.488### | 2.507 ± 0.182### | 5.373 ± 0.597### |
| Positive control | 2.137 ± 0.685 | 0.131 ± 0.037*** | 40.961 ± 5.748 | 1.910 ± 0.308 | 7.347 ± 0.004 |
| 100 mg/kg MPGL | 1.794 ± 0.209 | 0.254 ± 0.165*** | 55.865 ± 4.331 | 1.990 ± 0.201 | 5.910 ± 0.537 |
| 200 mg/kg MPGL | 1.802 ± 0.103 | 0.130 ± 0.001*** | 41.154 ± 6.626 | 1.950 ± 0.179 | 6.716 ± 0.268 |
| 400 mg/kg MPGL | 4.714 ± 0.772** | 0.083 ± 0.002*** | 24.038 ± 4.241** | 1.751 ± 0.219 | 8.283 ± 0.552 |
| Satellite control | 1.490 ± 0.391 | 1.267 ± 0.375 | 47.981 ± 6.664 | 2.587 ± 0.226 | 7.435 ± 0.152 |
**: Treatment group was compared with negative control group, p < 0.01.
***: Treatment group was compared with negative control group, p < 0.001.
###: Negative control group was compared with normal control, p < 0.001, using One-way ANOVA with Dunnett's test.
MPGL: Methanolic extract of Punica granatum leaves.
BUN: Blood Urea Nitrogen.
SEM: Standard error of mean.
ANOVA: Analysis of variance.