Table 3.

Summary of human genetic factors associated with Hodgkin’s lymphoma

Potential risk factor	Summary of results
HLA and associated genes:
HLA-A	A*01 associated with increased risk, A*02 with decreased risk [36]
	A*01:01 associated with increased risk [41]
HLA-B	B*08:01 associated with increased risk [41]
	B*07 and B*08 no association [29]
HLA region	Locus D6S265 allele 126 and locus D6S510 allele 284 heterozygotes and homozygotes (both HLA class I) associated with HL risk in a classic association analysis. (Other, weaker, associations also found.) Association lost when haplotype sharing statistic analysed [35]. Later narrowed down as above [36].
	HLA class I associated through seven SNPs – rs2530388, rs3823352, rs2256543, rs4713276, rs2523972, rs6457110, rs2517749 [76]. Later narrowed down as above [36].
	C*07:01 and DRB1*03:01 associated with increased risk [41]
	Genome-wide association study: rs6904029 (HCG9) associated with decreased risk or rs2734986 (HLA-G) associated with increased risk [34]
	rs6457715, near HLA-DPB1, associated with increased risk [30]
Cytokines and chemokines:
TNFA, TNFB	No association [35]
Other immune-related:
KIR	No clear association [52]

HL – Hodgkin’s lymphoma, HLA – human leukocyte antigen, KIR – killer-cell immunoglobulin-like receptors, SNP – single nucleotide polymorphism, TNF – tumour necrosis factor