Figure 7.

Intrathecal injection of PKA and p38MAPK inhibitors alleviates mechanical hyperalgesia. (a, b) Ipsilateral PWT (a) and contralateral PWT (b) after intrathecal injection of PKA and p38MAPK inhibitors (n = 9). Arrows indicate the time points at which inhibitors were administered. PWT was measured 2 h after inhibitor injection. ^∗∗∗P < 0.001 versus Sham group, ###P < 0.001 versus SNI group. (c) Western blots and quantification of spinal cord PKA and p-p38 expression (n = 3). ^∗P < 0.05 versus Sham group, ##P < 0.01, ###P < 0.001 versus SNI group. (d) Immunofluorescence images showing PKA expression in the dorsal horn of the spinal cord. PKA is green.