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. 2005 Apr 7;295(1):191–199. doi: 10.1016/j.ijpharm.2005.02.024

Table 3.

Parameters of the α–time curves fitted by Avrami equation (with n fixed at 2) together with the estimated weight percentages of metastable polymorph generated in hand-triturated and ball-milled R-RW samples at different time intervals

Time (min) Manual trituration
Ball milling
K R2 % (w/w) K R2 % (w/w)
0 0.003 (0.000) 0.997 0.000 (0.000) 0.003 (0.000) 0.907 0.000 (0.000)
1 0.019 (0.002) 0.949 0.004 (0.001) 0.005 (0.001) 0.905 0.000 (0.000)
3 0.027 (0.003) 0.921 0.010 (0.001) 0.012 (0.003) 0.742 0.001 (0.000)
6 0.038 (0.006) 0.914 0.022 (0.004) 0.018 (0.006) 0.618 0.004 (0.002)
10 0.060 (0.008) 0.952 0.064 (0.011) 0.041 (0.015) 0.722 0.026 (0.011)
20 0.146 (0.045) 0.878 0.532 (0.196) 0.067 (0.028) 0.624 0.084 (0.042)
30 0.178 (0.029) 0.968 0.851 (0.164) 0.058 (0.030) 0.429 0.059 (0.037)
40 0.235 (0.035) 0.969 1.643 (0.296) 0.151 (0.087) 0.444 0.576 (0.400)
50 0.304 (0.043) 0.973 3.025 (0.516) 0.158 (0.086) 0.437 0.642 (0.420)