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. 2018 Feb 19;108:9–13. doi: 10.1016/j.bios.2018.02.040

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© 2018 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — Schematic of DNA hydrogel formation through rolling circle amplification using agarose-based microbeads. (a) The templates are self-assembled to form an asymmetric dumbbell shape. And the primers are immobilized on the microbeads. (b) The templates are hybridized with primers immobilized on microbeads surface. (c) When the template on the microbead hybridized with a target pathogen, (d) the template can be ligated to form a closed-loop template. (e) RCA products are elongated by Phi29 polymerase. (f) The dumbbell-shaped long DNAs are aggregated with neighbor DNAs and form a DNA gel in bead voids.