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Diagram of the coronavirus replicase gene (encoding ORF 1a and 1b) illustrating the 5′ untranslated region (UTR), papain-like proteinase (PLpro), main protease (Mpro), RNA-dependent RNA polymerase (RdRp), metal-binding (MB), and RNA helicase (RH) domains. The arrows originating from PLpro and Mpro indicate the cleavage sites. The four regions amplified in this study are indicated as shading areas with arrow at each end (bottom).
