Fig. 2.

Transgenes for milk expression of antibodies. The gene of interest replaces the coding region of caprine β-casein, a milk specific gene. The promoter region (6.2 kb) linked to the coding regions of either light or heavy chains immunoglobulin, followed by untranslated caprine beta casein 3′ sequences and downstream elements (7.2 kb). Black boxes indicate the exons of the light and heavy chain of hBR96-2 (IgG1). Striped boxes indicate genomic introns. Arrows indicate direction of transcription.