Table 1.
Characteristics of patients with laboratory-confirmed MERS-CoV infection as of 12 May 2013a.6, 7, 10, 11, 12, 13, 14
| Case (WHO report date) | Demographics and epidemiological links |
Clinical manifestations |
Laboratory diagnosis (sample & date) | Treatment | |||||
|---|---|---|---|---|---|---|---|---|---|
| Sex/age | Comorbidities | Place of symptom onset (date) | Exposure Hx | Pneumonia / respiratory failure | ARF | Death (date) | |||
| 1 (23 Sep 12) |
M/60 | None | Bisha/KSA (6 Jun 12) | ? | Yes | Yes | Yes (24 Jun 2012) | 1. Viral culture (sputum 13 Jun 12 in LLC-MK2 & Vero cells) 2. Serum IgG (22 & 23 Jun 12; 1:20) 3. Pan-CoV RT-PCR & sequencing |
ICU: MV, oseltamivir, antibiotics |
| 2 (23 Sep 12) |
M/49 | None | Doha/Qatar (3 Sep 12) |
Kept camel and sheep in a farm | Yes | Yes | No (under Rx) |
Pan-CoV RT-PCR & sequencing (nose & throat swab 13 Sep 12, sputum 17 Sep 12, TA 19 Sep 12) | ICU: ECMO, oseltamivir, antibiotics, corticosteroid |
| 3 (23 Nov 12) |
M/45 | Heavy smoker, Atrophic R kidney DM, IHD |
Riyadh/KSA (9 Oct 12) |
Contacted farm animals (06/10/12) | Yes | Yes | No (recovered) | RT-PCR (URT 13 Oct 12, TA 23 Oct 12) | ICU: MV, RRT, oseltamivir, antibiotics |
| 4 (23 Nov 12) |
M/70 | ? | KSA (Oct 12) |
? | Yes | Yes | Yes | RT-PCR | Hospitalized |
| 5 (23 Nov 12) |
M/40+ | Heavy smoker | Qatar (5 Oct 12) |
Contacted an ill animal caretaker (camel and ill goats) | Yes | Yes | No (recovered) | RT-PCR (respiratory sample 17 Oct 12 & BAL 25 Oct 12) | ICU |
| 6 (23 Nov 12) |
? | ? | KSA (Oct 12) |
Household family member of case 4 | Yes | No | No (recovered) | RT-PCR | Hospitalized |
| 7 (30 Nov 12) |
? | ? | KSA (Oct 12) |
Household family member of case 4 | Yes | Yes | Yes | RT-PCR | Hospitalized |
| 8 (30 Nov 12) |
? | ? | Zarga/Jordan (Apr 12) |
? | Yes | No | Yes | ?RT-PCR | ICU |
| 9 (30 Nov 12) |
? | Yes | Zarga/Jordan (Apr 12) | ICU nurse of case 8 | Yes | No | Yes | ?RT-PCR | ? |
| 10 (11 Feb 13) |
M/60 | None | KSA (24 Jan 13) |
Travelled to Pakistan for 5 weeks and then to KSA (20-28 Jan 2012) before returning to UK (28 Jan 2012) No animal or patient contact | Yes | ? | Yes (Mar 13) | RT-PCR (throat swab 7 Feb 13) Coinfection: influenza A(H1N1)pdm09 (1 Feb 13) | ICU: ECMO |
| 11 (13 Feb 13) | M/38 | Malignancy with Rx | UK (6 Feb 13) |
Relative of case 10 | Yes | ? | Yes (17 Feb 2013) | RT-PCR (nose & throat swab 10 Feb 13) Coinfection: type 2 PIF (nose & throat swab 10 Feb 13) | ICU, ECMO |
| 12 (16 Feb 13) |
F/30 | None | UK (5 Feb 13) |
Relative of case 10 (total 2.5 h of contact) | No | No | No (recovered) | RT-PCR (sputum 13 Feb 13) Coinfection: type 2 PIF (nose & throat swab 15 Feb 13) |
Self-recovery (15 Feb 13) |
| 13 (21 Feb 13) |
? | ? | KSA (Jan 13) |
? | ? | ? | Yes (10 Feb 13) | ?RT-PCR (18 Feb 13) | Hospitalized |
| 14 (6 Mar 13) |
M/69 | ? | KSA (Feb 13) |
No patient contact ?animal contact |
? | ? | Yes (19 Feb 13) | ?RT-PCR (18 Feb 13) | Hospitalized |
| 15 (12 Mar 13) |
M/39 | ? | KSA (Feb 13) |
No patient contact ?animal contact |
? | ? | Yes (2 Mar 13) | ?RT-PCR (18 Feb 13) | Hospitalized |
| 16 (23 Mar 13) |
? | ? | KSA | Contact of case 15 | No | ? | No (recovered) | ?RT-PCR | Self-recovery |
| 17 (26 Mar 13) |
M/73 | ? | UAE (10 Mar 13) |
? | Yes | ? | Yes (26 Mar 13) | ?RT-PCR | Hospitalized |
| 18 (2 May 13) |
M/59 | Yes | Al-Hasa/KSA (14 Apr 13) |
Hospital cluster | Yes | ? | Yes (19 Apr 13) | ?RT-PCR | ICU |
| 19 (2 May 13) |
M/24 | Yes | Al-Hasa/KSA (17 Apr 13) |
Hospital cluster | Yes | ? | ?∗ | ?RT-PCR | ICU |
| 20 (2 May 13) |
M/87 | Yes | Al-Hasa/KSA (17 Apr 13) |
Hospital cluster | Yes | ? | Yes (28 Apr 13) | ?RT-PCR | ICU |
| 21 (2 May 13) |
M/58 | Yes | Al-Hasa/KSA (22 Apr 13) |
Hospital cluster | Yes | ? | ?∗ | ?RT-PCR | ICU |
| 22 (2 May 13) |
M/94 | Yes | Al-Hasa/KSA (22 Apr 13) |
Hospital cluster | Yes | ? | Yes (26 Apr 13) | ?RT-PCR | ICU |
| 23 (2 May 13) |
M/56 | Yes | Al-Hasa/KSA (22 Apr 13) |
Hospital cluster | Yes | ? | Yes (30 Apr 13) | ?RT-PCR | ICU |
| 24 (2 May 13) |
M/56 | Yes | Al-Hasa/KSA (22 Apr 13) |
Hospital cluster | Yes | ? | Yes (29 Apr 13) | ?RT-PCR | ICU |
| 25 (3 May 13) |
F/58 | Yes | Al-Hasa/KSA (27 Apr 13) |
Hospital cluster | Yes | ? | ?∗ | ?RT-PCR | ICU |
| 26 (3 May 13) |
M/50 | Yes | Al-Hasa/KSA (30 Apr 13) |
Hospital cluster | Yes | ? | ?∗ | ?RT-PCR | Hospitalized |
| 27 (3 May 13) |
M/33 | Yes | Al-Hasa/KSA (28 Apr 13) |
Hospital cluster, family contact of a deceased case | Yes | ? | ?∗ | ?RT-PCR | Hospitalized |
| 28 (6 May 13) |
F/62 | Yes | Al-Hasa/KSA (19 Apr 13) |
Hospital cluster | Yes | ? | Yes (3 May 13) | ?RT-PCR | ICU |
| 29 (6 May 13) |
M/71 | Yes | Al-Hasa/KSA (15 Apr 13) |
Hospital cluster | Yes | ? | Yes (3 May 13) | ?RT-PCR | ICU |
| 30 (6 May 13) |
F/58 | Yes | Al-Hasa/KSA (1 May 13) |
Hospital cluster | Yes | ? | ?∗ | ?RT-PCR | ICU |
| 31 (8 May 13) |
M/65 | Yes | Valenciennes/France (23 Apr 13) |
Travelled to Dubai, UAE in Apr 2013 | Yes | ? | ?∗ | RT-PCR: (BAL 7 May 13) | ICU |
| 32 (9 May 13) |
M/48 | Yes | Al-Hasa/KSA (29 Apr 13) |
Hospital cluster | Yes | ? | ?∗ | ?RT-PCR (8 May 13) | Hospitalized |
| 33 (9 May 13) |
M/58 | Yes | Al-Hasa/KSA (3 May 13) |
Hospital cluster | Yes | ? | No (recovered) |
?RT-PCR (8 May 13) | Discharged (3 May 13) |
| 34 | ?/? | ? | Valenciennes/France | Stayed in the same hospital room with case 31 | ? | ? | ? | ?RT-PCR (11-12 May 13) | ? |
Abbreviations: ARF, acute renal failure; BAL, bronchoalveolar lavage; CoV, coronavirus; DM, diabetes mellitus; F, female; h, hour; Hx, history; ICU, intensive care unit; IgG, immunoglobulin G; IHD, ischemic heart disease; LRT, lower respiratory tract; M, male; MV, mechanical ventilation; PIF, parainfluenza virus; R, right; RRT, renal replacement therapy; RT-PCR, reverse transcription polymerase chain reaction; Rx, treatment; TA, tracheal aspirate; UAE, United Arab Emirates; URT, upper respiratory tract.
∗
Two additional deaths were reported among these cases. The others are under treatment.
a
As of 23 June 2013, after the acceptance of the article, the total number of laboratory-confirmed cases have increased to 70 with 39 fatalities.