Scheme 4.
Synthesis of L-tert-leucyl thiazolide prodrugs. Reagents: i) Boc-Tle-OH 6, EDC, DMAP, THF or DMF, 65%; ii) HCl-dioxane, 0–20 °C, 95%. Abbreviation: Tle = L-tert-leucine, (2S)- 2-amino-3,3-dimethylbutanoic acid [24].
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