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Dosing schedules for safety pharmacology study of RM5061 8a in rats. One untreated group was kept as a control; for full details, see supporting information.
| Indication | Grouping | Dose employed mg/kg | ||
|---|---|---|---|---|
| CNS | 3 groups, 10 rats each (5M/5F) | 100 | 300 | 1000 |
| Respiratory | 3 groups, 6 rats each (3M/3F) | 100 | 300 | 1000 |
