Table 2.
Potential microbial etiology of community-acquired pneumonia in 59 evaluable patients.
| Etiologic category | Method of detection | Standard bundle (n = 28) | FilmArray bundle (n = 31) | Total (%) of 59 |
|---|---|---|---|---|
| No pathogen identified | Not applicable | 4 | 9 | 22.0 |
| Virus only | Multiplex PCR | 7 | 11 | 30.5 |
| Bacterial only, total | 10 | 5 | 25.5 | |
| S. pneumoniae PCRa | 4 | 3 | ||
| S. pneumoniae urine antigena | 1 | 1 | ||
| S. aureus PCR | 3 | 1 | ||
| L. pneumophila urine antigen | 1 | 0 | ||
| C. pneumophila PCR | N/A | 1 | ||
| Sputum culture | 3b | 3c | ||
| Blood culture | (S. pneumoniae) 2 | |||
| No bacteria; procalcitonin ↑ | 0 | 0 | ||
| Virus a bacteria, total | 7 | 6 | 22.0 | |
| Virus: | Viral PCR | 7 | 6 | |
| Bacteria: | S. pneumoniae PCRa | 2 | 2 | |
| S. pneumoniae urine antigena | 2 | 1 | ||
| S. aureus PCR | 1 | 1 | ||
| L. pneumophila urine antigen | 0 | 0 | ||
| Sputum culture | 0 | 2 | ||
| Blood culture | 0 | 0 | ||
| No bacteria; PCT ↑ | 3 | 0 | ||
| Total number of pathogens detected | All methods | 24/28 (85) | 22/31 (70) | 46/59 (78) |
a
Of the total of 11 patients with a positive NP swab PCR for S. pneumoniae, there were 4 patients with a concomitant positive S. pneumoniae urine antigen, 3 patients with concomitant positive sputum culture, and 2 patients with concomitant positive blood cultures.
b
S. pneumoniae in 2; MSSA in 1.
c
S. pneumoniae in 2; M. tuberculosis in 1.