Table 2.
Resistance mechanisma | Number of isolates | MIC (μg/mL) |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Imipenem |
Meropenem |
Doripenemb |
||||||||
Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | ||
OprD | 7 | 32–32 | 32 | 32 | 8–64 | 32 | 64 | 4 to >32 | 16 | >32 |
VIM | 12 | 32 to >256 | 32 | 128 | 8–256 | 32 | 128 | 4 to >32 | >32 | >32 |
OprD + VIM | ||||||||||
Overall | 28 | 32–256 | 256 | 256 | 8–256 | 128 | 128 | 12 to >32 | >32 | >32 |
Altered MexA | 5 | 32–256 | 32 | 256 | 8–256 | 32 | 128 | 32 to >32 | >32 | >32 |
Normal MexA | 23 | 32–256 | 256 | 256 | 32–256 | 128 | 128 | 12 to >32 | >32 | >32 |
MIC50/90, MICs that inhibited the growth of 50% and 90% of the organisms, respectively.
Isolates with either reduced OprD expression only or the presence of blaVIM only, or both, were designated as ‘OprD’, ‘VIM’ and ‘OprD + VIM’, respectively.
MICs of doripenem were determined using Etest only.