Table 1.
Cytotoxicity of Sinupret® preparations (oral drops and dry extract). Inhibitory concentration (IC50, μg/ml).
| MTT-assay |
|||||
|---|---|---|---|---|---|
| MDCK | HEp-2 | HeLa | BGM | Highest concentration used in the antiviral tests | |
| IC50 | |||||
| Oral drops | 543 | 930 | 827 | 516 | 120 |
| Dry extract | >500 | >500 | >500 | >500 | 100 (500a) |
The cytotoxicity on the respective cells (MDCK, HEp-2, HeLa and BGM) cultivated with different concentrations of the Sinupret® preparations (range: 1240–0.1 μg/ml) and the corresponding ethanol (ethanol range: 3.8–0.0003%) solutions were quantified using an MTT-assay. The relative cytotoxicity of the Sinupret® preparations was standardised by the medium control representing 100% viability. The table shows the concentration-dependent intoxication of Sinupret® calculated as a 50% inhibitory concentration (IC50). All data represent four replicates.
a
Concentration used in the additional tests with FluA and pFluA.