Table 3.

In vitro cytotoxicity of synthesized compounds (2–11)

Compound no.	GI50 (μM)a
	MDA-MB-468	MCF-7
2	13.72 ± 0.51	11.52 ± 0.25
3	10.85 ± 0.34	8.22 ± 0.10
4	11.01 ± 0.29	51.57 ± 0.59
5	8.73 ± 0.11	36.77 ± 0.45
6	11.47 ± 0.12	13.25 ± 0.28
7	12.85 ± 0.15	14.47 ± 0.31
8	14.09 ± 0.17	12.90 ± 0.27
9	10.86 ± 0.11	14.47 ± 0.33
10	7.35 ± 0.10	14.80 ± 0.35
11	–b	–b
Chloroquine	24.36 ± 0.25	20.72 ± 0.23
Amodiaquine	17.80 ± 0.09	13.01 ± 0.27
Mefloquine	18.25 ± 0.10	10.60 ± 0.68

^aGI₅₀, concentration of drug to reduce cell number to 50% of control cultures.

^bNot determined.