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. 2006 Oct 12;14(24):8295–8306. doi: 10.1016/j.bmc.2006.09.014

Figure 5.

Figure 5

Dose–response plot for quercetin-3-β-galactoside on the proteolytic activity inhibition of SARS-CoV 3CLpro and SARS-CoV 3CLpro Q189A. Inhibition of cleavage was measured by FRET using a peptide substrate labeled with a pair of fluorogenic dyes. IC50 values were calculated from the curves using nonlinear regression analysis. IC50 value for quercetin-3-β-galactoside on SARS-CoV 3CLpro is 42.79 ± 4.97 μM (A). IC50 value for quercetin-3-β-galactoside on SARS-CoV 3CLpro Q189A is 127.89 ± 10.06 μM (B).