Table 2.

Inhibitory activity of the selected compounds against mutant RTs

HIV-1 RT	Ki (μМ)
	19	30	32	33	34	NVP	EFV
WT	0.26	0.55	0.67	0.31	0.31	7.2	0.01
L100I	0.13	0.76	0.92	0.36	0.24	273	0.08
K103N	>26	12	15.5	9.4	6.9	>2000	0.58
V106A	7.5	2.9	11	4.2	2.3	>2000	0.05
Y181C	169	75	43	25	20	>2000	0.03
G190A	0.36	0.4	0.55	0.3	0.18	>2000	0.06
K103N/Y181C	>26	>100	>100	>100	85	>2000	0.14