Table 2.
Mammalian proteins involved in GPI -AP biogenesis.
| step | protein | function | step | protein | function |
|---|---|---|---|---|---|
| 1 | PIGA | GPI-GnT, catalytic | 13 | PIGK | GPI transamidase, catalytic 1 |
| 1 | PIGC | GPI-GnT | 13 | GPAA1 | GPI transamidase, catalytic 2 |
| 1 | PIGH | GPI-GnT | 13 | PIGS | GPI transamidase |
| 1 | PIGQ | GPI-GnT | 13 | PIGT | GPI transamidase |
| 1 | PIGP | GPI-GnT | 13 | PIGU | GPI transamidase |
| 1 | PIGY | GPI-GnT | 14 | PGAP1 | inositol-deacylase |
| 1 | DPM2 | GPI-GnT, regulatory | 15 | PGAP5/MPPE1 | EtNP phosphodiesterase |
| 2 | PIGL | GlcNAc-PI-deacetylase | 16 | p24α2 | cargo receptor |
| 3 | ? | flipping | 16 | p24β1 | cargo receptor |
| 4 | PIGW | GlcN-PI-acyltransferase | 16 | p24γ2 | cargo receptor |
| 5 | ? | lipid remodelling | 16 | p24δ1 | cargo receptor |
| 6 | PIGM | GPI-MTI, catalytic | 17 | PGAP3 | fatty acid remodelling, PLA2 |
| 6 | PIGX | GPI-MTI, regulatory | 18 | PGAP2 | fatty acid remodelling, reacylation |
| 7 | PIGV | GPI-MTII | 19 | PGAP4/TMEM246 | GPI-GalNAcT |
| 8 | PIGN | GPI-ETI | 20 | B3GALT4 | GPI-GalT |
| 9 | PIGB | GPI-MTIII | 21 | ? | GPI-SiaT |
| 10 | PIGO | GPI-ETIII, catalytic | |||
| 10/11 | PIGF | GPI-ETII/III, regulatory | |||
| 11 | PIGG | GPIETII, catalytic | |||
| 12 | PIGZ | GPI-MTIV |