Table 1.

Key Table

Secretor Status Profoundly Influences Infection and Disease Susceptibility^a

Infection	Secretors more susceptible	Nonsecretors more susceptible	Refs
Norovirus (GII.4)	✔		21, 74
Rotavirus (VP8)	✔		36, 37, 38
Influenza A virus	✔		[19]
Rhinovirus	✔		[19]
Echovirus	✔		[19]
RSV	✔		[19]
HIV	✔		16, 17, 18
Helicobacter pylori	✔		24, 75, 76
Candida albicans		✔	77, 78
Streptococcus pneumoniae		✔	[22]
Neisseria meningitidis		✔	[22]
Haemophilus influenzae		✔	[23]
Salmonella enterica serovar Typhimuriumb		✔	[11]
Citrobacter rodentiumb		✔	[9]
Campylobacter jejuni		✔	41, 42
Urinary tract infection		✔	79, 80
Bacteraemia (after haematopoietic stem cell transplantation)		✔	[81]
Disease	Secretors more susceptible	Nonsecretors more susceptible	Refs
Non-CF bronchiectasis severityc	✔		[67]
Asthma severity	✔		[82]
Graft-versus-host disease	✔		[81]
Intestinal-type gastric cancer		✔	[83]
Primary sclerosing cholangitis		✔	[84]
Crohn’s disease		✔	53, 85
Celiac disease		✔	[86]
Asthma		✔	26, 27
Type 1 diabetes		✔	[28]
High plasma vitamin B12		✔	87, 88, 89
Chronic pancreatitis		✔	[25]
Psoriasis		✔	[29]
Acute uncomplicated pyelonephritis		✔	[90]
Behçet’s disease		✔	[91]

^aSecretor phenotype is associated with increased susceptibility to viral infections and respiratory disease severity, but with decreased susceptibility to bacterial infections and a diverse range of chronic inflammatory diseases.

^bDemonstrated in Fut2^–/– mice with no human epidemiological evidence.

^cAbbreviation: CF, cystic fibrosis.