Table 2.

Biological evaluation of AraU phosphoramidates in leukaemia cell lines (IC₅₀ μM)

Compound	Ar	AA	Ester	NB4	HL60	KG1	U937	L1210	CEM
AraU (3)	—	—	—	69	90	25	>100	170	>500
4	Ph	d-Ala	Bn	88	92	90	>100	470	313
5	Ph	l-Ala	Bn	38	>100	63	92	184	188
6	Ph	l-Ala	Me	53	>100	32	>100	>500	>500
7	Ph	Gly	Bn	52	>100	39	>100	256	196
8	1-Naph	l-Ala	iPr	77	84	67	>100	250	181