Table 1.
Survival data for animals challenged with PVM.
| Immunogen | BAlb/c† | C3H–He-mg | C57BL/6 | |||
|---|---|---|---|---|---|---|
| 107 pfu (×1) | 108 pfu (×1) | 107 pfu (×2) | 108 pfu (×2) | 107 pfu (×2) | 107 pfu (×2) | |
| rAd5-N | 6/6 | 5/5 | 3/3 | 6/6 | 5/5 | 5/5 |
| rAd5-M | 3/6 | 6/6 | 5/6 | 6/6 | 3*/5 | 5/5 |
| rAd5-Z | 1/6 | 6/6 | 0/6 | 4/4 | 2*/5 | 5*/5 |
| PBS | 0/2 | 0/2 | 0/4 | 2*/4 | 0/4 | 0/4 |
†
Mice were inoculated i.n. with one (×1) or two (×2) doses of Ad5 immunogens, at day 0 and 14, and were challenged i.n. at day 42 (×1) or day 28 (×2) with a lethal dose of PVM.
*
Mice exhibited elevated clinical signs of disease.