Table 1.
C-type lectin receptors that bind endogenous and exogenous ligands.
| Receptor | Type | Ligands (selected) | Expression | Regulation | References |
|---|---|---|---|---|---|
| MR | I | Endogenous and exogenous ligands bearing mannose, fucose, N-acetyl glucosamine and sulphated sugars via cysteine rich domain | MØ, DC subsets, lymphatic and hepatic endothelium | ↑ PGE, IL-4, IL-10, IL-13 ↓ IFN-γ, LPS | 54., 68., 69. |
| Endo-180 | I | Mannose, fucose and N- acetylglucosamine via CRD 2, collagen via FNII domain | Fibroblasts, MØ, subset of endothelial cells | Unknown | |
| DC-SIGN | II | HIV and other pathogens due to mannose type CRD. ICAM-2 and -3 via CRD. | DCs, alveolar and decidual MØ | ↑ IL-13 ↓ LPS | [70] |
| DC-SIGNR | II | Similar to DC-SIGN | Hepatic and lymphatic endothelium | Unknown | |
| SIGNR1 | II | Mannose-type CRD, dextran, Streptococcus pneumoniae CPS, Candida albicans, HIV, ICAM-3 | MZ MØ, peritoneal MØ | Unknown | |
| Langerin | II | Mannose, fucose, N-acetylglucosamine | Langerhans cells, subset of DCs | ↑ TGF-β↓ LPS, CD40-L | 71., 72. |
| BDCA-2 | II | Unknown | Plasmacytoid DCs | Unknown | |
| Dectin-2 | II | Conflicting evidence for mannose type ligands CD4+/CD25+ T-cell ligand | DC, MØ, Langerhans cells | Unknown | |
| Dectin-1/β-glucan receptor | II | β-1,3- and β-1,6-linked glucans from fungi T-cell ligand | MØ, DC, PMN, T cell | ↑ IL-4, IL-13 ↓ IL-10, LPS | [73] |
Abbreviations: MZ, marginal zone; PGE, prostaglandin E.