Table 2.
Antiviral Drugs in Active Clinical Stage Development.
| Name | Indication | Phase | Type | Mono/Combo | Company | NCT or other references |
|---|---|---|---|---|---|---|
| ABI-H0731(CpAM) | HBV | 2 | Small Molecule | Mono | Assembly Biosciences | NCT03109730 |
| ARB-1467 | HBV | 2 | Oligonucleotide | Mono | Arbutus Biopharma | NCT02631096 |
| AB-423 | HBV | 1 | Small Molecule | Mono | Arbutus Biopharma | http://bit.ly/2GShPvO |
| ALN-HBV | HBV | 2 | Oligonucleotide | Mono | Alnylam Pharmaceuticals | NCT02826018 |
| Morphothiadine | HBV | 2 | Small Molecule | Mono | HEC Pharm | ChiCTR-IIR-16008284 |
| AL-034 | HBV | 1 | Small Molecule | Mono | Janssen Pharmaceuticals | NCT03285620 |
| RO6870868 | HBV | 2 | Small Molecule | Combo | Roche | NCT02391805 |
| Tenofovir Exalidex | HBV | 2 | Small Molecule | Mono | Contravir | NCT02710604 |
| Inarigavir (SB 9200) | HBV | 2 | Small Molecule | Combo | Spring Bank Pharmaceuticals | NCT02751996 |
| REP 2139 | HBV | 2 | Oligonucleotide | Mono | Replicor Inc. | NCT02233075 |
| REP 2165 | HBV | 2 | Oligonucleotide | Mono | Replicor Inc. | NCT02565719 |
| GSK-3389404 | HBV | 2 | Oligonucleotide | Mono | GlaxoSmithKline | NCT03020745 |
| GSK-3228836 | HBV | 2 | Oligonucleotide | Mono | GlaxoSmithKline | NCT02981602 |
| JNJ-379 | HBV | 1 | Small Molecule | Mono | Janssen Pharmaceuticals | NCT03361956 |
| RG-7907 | HBV | 1 | Small Molecule | Mono | Roche | NCT02952924 |
| GS-9688 | HBV | 1 | Small Molecule | Mono | Gilead Sciences | ACTRN12617000235303 |
| RG-6004 | HBV | 1 | Oligonucleotide | Mono | Roche | NCT03038113 |
| RG-7854 | HBV | 1 | Small Molecule | Mono | Roche | NCT02956850 |
| INO-9112 | HBV | 1 | Small Molecule | Mono | Roche/Inovio | NCT02431312 |
| GS-5801 | HBV | 1 | Small Molecule | Mono | Gilead Sciences | ACTRN12616001260415 |
| Myrcludex B | HBV | 2 | Peptide | Mono | MYR Pharma | NCT02637999 |
| EYP-001 | HBV | 1 | Small Molecule | Mono | Enyo Pharma | NCT03272009 |
| GC1102 | HBV | 2 | Protein | Mono | Green Cross | NCT02304315 |
| Hepalatide (L47) | HBV | 1 | Peptide | Mono | Shanghai HEP Pharmaceuticals | NCT02612506 |
| Besifovir | HBV | 3 | Small Molecule | Mono | Il-Dong | NCT02792088 |
| Tenofovir disoproxil orotate | HBV | 3 | Small Molecule | 816. Mono | 817. Dong-A ST | 818. NCT02967939 |
| Tenofovir disoproxil aspartate | HBV | 3 | Small Molecule | Mono | Chong Kun Dang Pharmaceutical Corp. | NCT02805738 |
| QL-007 | HBV | 1 | Small Molecule | Mono | Qliu Pharmaceuticals | NCT03244085 |
| APG-1387 | HBV | 1 | Small Molecule | Mono | Ascentage Pharma | NCT03386526 |
| AT-527 | HCV | 1 | Small Molecule | Mono | Atea Pharmaceuticals | NCT03219957 |
| Faldaprevir | HCV | 3 | Small Molecule | Mono | Trek Therapeutics/Boehringer Ingelheim | NCT02716428 |
| VX-222 | HCV | 2 | Small Molecule | Mono | Trek Therapeutics/Vertex | NCT01516918 |
| VX-497 | HCV | 2 | Small Molecule | Mono | Trek Therapeutics/Vertex | NCT00088504 |
| Ravidasvir | HCV | 2 | Small Molecule | Mono | Presidio | NCT02961426 |
| TD-6450 | HCV | 2 | Small Molecule | Mono | Trek Therapeutics/Theravance | NCT02716428 |
| ABX464 | HIV | 2 | Small Molecule | Mono | Abivax | NCT02990325 |
| Bictegravir/F/TAF (non-boosted integrase inhibitor/emtricitabine/tenofovir alafenamide) (Biktarvy®) | HIV | 3 | Small Molecule | Combo | Gilead Sciences | NCT02603107 |
| LA cabotegravir | HIV | 3 | Small Molecule | Mono | ViiV Healthcare | NCT02478463 |
| LA cabotegravir + LA rilpivirine | HIV | 3 | Small Molecule | Combo | Janssen/ViiV Healthcare | NCT02951052 |
| Darunavir STR darunavir/cobicistat/emtricitabine/tenofovir alafenamide (Symtuza®) | HIV | 3 | Small Molecule | Combo | Janssen Pharmaceuticals | NCT02578550 |
| dolutegravir + lamivudine | HIV | 3 | Small Molecule | Combo | ViiV Healthcare | NCT02211482 |
| Doravirine | HIV | 3 | Small Molecule | Mono | Merck | NCT02275780 |
| Doravirine/lamivudine/tenofovir disoproxil fumarate | HIV | 3 | Small Molecule | Combo | Merck | NCT03332095 |
| Elsulfavirine | HIV | 3 | Small Molecule | Mono | Viriom | NCT02489461 |
| Fostemsavir | HIV | 3 | Small Molecule | Mono | ViiV Healthcare | NCT01384734 |
| Ibalizumab | HIV | 3 | Protein | Mono | US TaliMed Biologics | NCT02707861 |
| PRO 140 | HIV | 3 | Protein | Mono | CytoDyn | NCT02483078 |
| BIT-225 | HIV | 2 | Small Molecule | Mono | Biotron | ACTRN12613001296729 |
| SB-728-T | HIV | 2 | Gene Therapy | Mono | Sangamo Therapeutics | NCT01543152 |
| UB-421 | HIV | 3 | Protein | Mono | United Biopharma | NCT03045861 |
| MK8591 | HIV | 1 | Small Molecule | Mono | Merck | NCT02369146 |
| ALT-803 | HIV | 1 | Protein | Mono | Altor BioScience | NCT03272347 |
| Vesatolimod (GS-9620) | HIV | 1 | Small Molecule | Mono | Gilead Sciences | NCT02191098 |
| TMB-607 | HIV | 1 | Small Molecule | Mono | TaiMed Biologics | NCT02858401 |
| VRC01LS | HIV | 1 | Protein | Mono | Xencor/NIH | NCT03110549 |
| CAL-1 | HIV | 2 | Gene Therapy | Mono | CalImmune | NCT02797171 |
| GS-9722 | HIV | 1 | Protein | Mono | Gilead Sciences | NCT02390297 |
| MK-4250 | HIV | 1 | Small Molecule | Mono | Merck | |
| PGT-121 | HIV | 1 | Protein | Mono | Theraclone Sciences | NCT03351699 |
| Baloxavir marboxil (Xofluza®) | Influenza | 3 | Small Molecule | Mono | Roche (Shionogi) | NCT02954354 |
| VIS-410 | Influenza | 3 | Protein | Mono | Visterra | NCT03040141 |
| MEDI-8852 | Influenza | 2 | Protein | Mono | AstraZeneca | NCT02603952 |
| Pimodivir (JNJ-872) | Influenza | 3 | Small Molecule | Mono | Janssen Pharmaceuticals | NCT03376321 |
| JNJ-5806 | Influenza | 2 | Small Molecule | Mono | Janssen Pharmaceuticals | NCT03411421 |
| NT-300 | Influenza | 3 | Small Molecule | Mono | Romark Laboratories | NCT03336619 |
| FluDase | Influenza | 2 | Protein | Mono | Ansun Biopharma | NCT01113034 |
| Laninamivir Octanoate | Influenza | 2 | Small Molecule | Mono | Aviragen | NCT02014649 |
| Radavirsen | Influenza | 1 | Oligonucleotide | Mono | Sarepta Therapeutics | NCT01747148 |
| RV-521 | RSV | 2 | Small Molecule | Mono | ReViral | NCT03258502 |
| Presatovir (GS-5806) | RSV | 2 | Small Molecule | Mono | Gilead Sciences | NCT02534350 |
| Lumicitabine (ALS-8176) | RSV | 2 | Small Molecule | Mono | Janssen Pharmaceuticals | NCT02935673 |
| ALX-0171 | RSV | 2 | Protein | Mono | Ablynx | NCT02979431 |
| AK0529 | RSV | 2 | Small Molecule | Mono | Ark Biosciences | NCT03400995 |
| JNJ-678 | RSV | 2 | Small Molecule | Mono | Janssen Pharmaceuticals | NCT02593851 |
| MEDI8897 | RSV | 2 | Protein | Mono | AstraZeneca | NCT02878330 |
| PC-786 | RSV | 1 | Small Molecule | Mono | Pulmocide | NCT03382431 |
| EDP-938 | RSV | 1 | Small Molecule | Mono | Enanta Pharmaceuticals | NCT03384823 |
| GS-5734 | Ebola Virus | 2 | Small Molecule | Mono | Gilead Sciences | NCT02818582 |
| BTA074 | HPV | 2 | Small Molecule | Mono | Aviragen Therapeutics | NCT01532102 |
| Pritelivir | HSV | 2 | Small Molecule | Mono | AiCuris | NCT03073967 |
| Ranpirnase | HPV | 2 | Small Molecule | Mono | Tamir Biotechnology | NCT02535104 |
| DAS181 | Para-influenza/Influenza Virus | 3 | Protein | Mono | Ansun Biopharma | NCT01644877 |
| ATA 129 | Epstein-Barr Virus | 2 | Cell Therapy | Mono | Atara Biotherapeutics | NCT03392142 |
| Tecovirimat | Smallpox (Variola Virus) | 3 | Small Molecule | Mono | SIGA | NCT02080767 |
| Modipafant | Dengue Virus | 2 | Small Molecule | Mono | 60 Degrees Pharmaceuticals | NCT02569827 |
| Celgosivir | Dengue Virus | 2 | Small Molecule | Mono | 60 Degrees Pharmaceuticals | NCT02569827 |
| Maribavir (SHP-620) | CMV | 3 | Small Molecule | Mono | Shire Pharmaceuticals | NCT02931539 |
| Cyclopropavir (MBX-400) | CMV | 1 | Small Molecule | Mono | Microbiotix Inc. | NCT02454699 |
| SHP-640 | Adenoviral Conjunctivi-tis | 3 | Small Molecule | Combo | Shire Pharmaceuticals | NCT02998554 |
| Brincidofovir | Adenovirus/Smallpox (Variola Virus)/CMV | 2/3 | Small Molecule | Mono | Chimerix | NCT02596997 |
| Viralym M | CMV, AdV, BKV, EBV HHV-6 | 2 | Cell Therapy | Mono | ViraCyte | NCT02765802 |
| Viralym C | CMV | 1 | Cell Therapy | Mono | ViraCyte | NCT02313857 |
| Lonafarnib | HDV | 2 | Small Molecule | Mono | Eiger Biopharma | NCT02527707 |
| Pegylated-interferon-lambda (PEG-IFN-λ) | HDV | 2 | Protein | Mono | Eiger Biopharma | NCT02765802 |
| SB206 | HPV | 2 | Small Molecule | Mono | Novan Therapeutics | NCT03436615 |
| VP-102 | HPV | 2 | Small Molecule | Mono | Verrica Pharmaceuticals | NCT03377803 |
| SAB-301 | Corona-virus | 1 | Protein | Mono | SAb Biotherapeutics | NCT02788188 |
| ZMapp | Ebola Virus | 1 | Protein | Mono | Mapp Biopharma | NCT02389192 |
Viruses.
HIV-1= Human immunodeficiency virus-1.
HCV= Hepatitis C virus.
HBV= Hepatitis B virus.
HDV= Hepatitis D virus.
CMV= Cytamegalovirus.
HSV= Herpes simplex virus.
HPV= Human papillomavirus.
AdV = Adenovirus.
BKV= BK virus.
EBV = Epstein-Barr virus.
HHV-6= Human herpesvirus-6.
Other abbreviations.
Mono = Monotherapy.
Combo = Combination therapy.