Scheme 2.
Reagents and conditions: (i) NaN3, DMF, rt, 3 d; (ii) (1) Ph3P, toluene, rt, 1 h; (2) H2O; (iii) NEt3, DCM, rt, 20 h; (iv) K2CO3, DMF, 50 °C, 3 d; (v) NaH, DMF, rt, 10 h; (vi) K2CO3, DMF, rt, 3 d.
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