Table 3.

Summary of drugs that have been reported to present different degrees of intestinal lymphatic transport.

Compound	Log P	Formulation and feeding status	Species	Percentage (%) of absorbed dose in lymph	Reference
Δ4-androstan-17-β-methoxycyclopentyl ether (Δ4-AE)	6.6	Long chain triglyceride	Rat	96.77	Ichihashi et al. [177]
2α,3α-epithio-5α-androstan-17-one (KEP)	3	Long chain triglyceride	Rat	7.98	Ichihashi et al. [177]
5α-androst-2-en-17-one (KO)	4.6	Long chain triglyceride	Rat	6.49	Ichihashi et al. [177]
CI-976	5.8	Long chain triglyceride	Rat	43	Hauss et al. [179]
CI-976	5.83	Triglyceride emulsion	Rat	< 1	Hauss et al. [179]
Cyclosporin A	2.99	Micellar solution	Rat	~ 2	Takada et al. [283]
Cyclosporin A	2.99	Long chain triglyceride	Rat	2.16	Ueda et al. [276]
Dehydrotestosterone-17β-methoxycyclopentyl ether (DHTE)	5.4	Long chain triglyceride	Rat	28.35	Ichihashi et al. [177]
Dichlorodiphenyltrichloroethane (DDT)	6.19	Triglyceride emulsion	Rat	15	Myers and Stella [178]
Epitiostanol	4.4	Long chain triglyceride	Rat	4.53	Ichihashi et al. [284]
Etretinate	7.8	Long chain triglyceride	Rat	25.71	Nankervis et al. [278]
Halofantrine	8.5	Emulsion	Rat	12	Porter et al. [133]
Halofantrine	8.5	Micellar	Rat	18	Porter et al. [133]
Halofantrine	8.5	Triglyceride lipid	Rat	17	Porter et al. [132]
Halofantrine	8.5	Micellar	Rat	20	Porter et al. [132]
Halofantrine	8.5	Long chain triglyceride	Rat	16	Caliph et al. [152]
Halofantrine	8.5	Fasted	Dog	1.3	Khoo et al. [282]
Halofantrine	8.5	Fed	Dog	54	Khoo et al. [94]
Halofantrine (hydrochloride salt)	8.5	Fatty acid/monoglycerol solution	Rat	~ 5	Porter et al. [132]
Halofantrine (hydrochloride salt)	8.5	Fed	Dog	44	Khoo et al. [282]
Hexachlorobenzene (HCB)	6.53	Triglyceride emulsion	Rat	~ 3	Myers and Stella [178]
Isotretinoin	6.8	Long chain triglyceride	Rat	1.99	Nankervis et al. [278]
Lu28-179	8	Triglyceride emulsion	Rat	4.5	Neilson et al. [285]
Mepitiostane (prodrug of Epitiostanol)	6.06	Triglyceride	Rat	41	Ichihashi et al. [243]
Mepitiostane (prodrug of Epitiostanol)	6	Long chain triglyceride	Rat	92.59	Ichihashi et al. [284]
Mepitiostaneolefin	5.1	Long chain triglyceride	Rat	97.67	Ichihashi et al. [177]
MK-386	8.6	Triglyceride	Rat	0.1	Kwei et al. [286]
MK-386	8	Long chain triglyceride	Rat	1.67	Kwei et al. [286]
Ontazolast	4	Triglyceride emulsion	Rat	1.25	Hauss et al. [277]
Ontazolast	4	SEEDS	Rat	0.7	Hauss et al. [277]
Ontazolast	4	Long chain triglyceride	Rat	69.6	Hauss et al. [179]
p,p-DDT	6.2	Long chain triglyceride	Rat	51.6	O'Driscoll et al. [281]
Penclomedine	5.48	Triglyceride emulsion	Rat	~ 3	Myers and Stella [178]
Progesterone	3.9	Long chain triglyceride	Rat	0.82	Ichihashi et al. [177]
Temarotene	8.7	Long chain triglyceride	Rat	45.67	Nankervis et al. [278]
Testosterone	3.3	Long chain triglyceride	Rat	0.11	Ichihashi et al. [177]
Testosterone-17-β-methoxycyclopentyl ether	6.2	Long chain triglyceride	Rat	12.48	Ichihashi et al. [177]
Vitamin D3	7.9	Triglyceride emulsion	Rat	19.2	Liu et al. [287]