TABLE I.
Primary Sequences of Peptides Hydrolyzed by ACE and ACE2
| ACE |
ACE2 |
||
|---|---|---|---|
| Substrate | Sequence | Substrate | Sequence |
| Ang I | DRVYIHPF↓HL | Ang I | DRVYIHPFH↓L |
| Ang (1-9) | DRVYIHP↓FH | Ang II | DRVYIHP↓F |
| Ang (1-7) | DRVYI↓HP | Apelin 18 (36) | (…)QRPRLSHKGPMP↓F |
| Bradykinin | RPPGF↓SP↓FR | Des-Arg9 bradykinin | RPPGFSP↓F |
| Enkephalins | YGG↓FM(L)-NH2 | β-Casamorphin | YPFVEP↓I |
| Substance P | RPLPQQFF↓G↓LM-NH2 | Neocasamorphin | YPVEP↓I |
| LH-RH | EHW↓SGLRPG | Dynorphin A 1-13 | YGGFLRRIRPKL↓K |
| Haemoregulatory peptide | NAcSD↓KP | Neurotensin 1-8 | Pe-LYENKP↓R |
| CCK-8 | NY↓(SO3H)MGWM↓DF-NH2 | ||
Cleavage sites are indicated by an arrow.