Table 2.
Quantitative data for GST-P positive foci, CK8/18+ foci and liver tumors in rats undergoing initiation with DEN, with or without subsequent PB treatment.
| No. of rats | DENa | No. of rats | DEN → PB | |
|---|---|---|---|---|
| GST-P+ foci (≥ 0.2 mm) | ||||
| Number (no./cm2) | 10 | 128.04 ± 16.51 | 10 | 161.91 ± 36.59b |
| Area (mm2/cm2) | 1.41 ± 0.54 | 3.08 ± 0.92d | ||
| CK8/18+ foci | ||||
| Number (No./cm2) | 10 | 1.82 ± 0.42 | 10 | 4.17 ± 1.41b |
| Area (mm2/cm2) | 0.26 ± 0.07 | 0.70 ± 0.15c | ||
| Liver tumors | ||||
| Incidence (%) | ||||
| Adenoma | 20 | 20(100) | 20 | 20(100) |
| HCC | 19(95) | 20(100) | ||
| Multiplicity (No./rat) | ||||
| Adenoma | 3.65 ± 1.90 | 4.10 ± 2.86 | ||
| HCC | 3.00 ± 1.95 | 9.60 ± 3.15d | ||
| Total | 6.65 ± 2.64 | 13.7 ± 3.53d | ||
aData are mean ± SD.
b–dSignificantly different from the DEN initiation control group.
bP < 0.01; cP < 0.001; dP < 0.0001.