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. 2003 Sep 10;315(1):20–33. doi: 10.1016/S0042-6822(03)00323-4

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Copyright © 2003 Elsevier Inc. All rights reserved.

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Fig. 6 — Cytotoxic effect of HCoV-OC43 infection in the CNS of C57BL/6 mice (21 DPN) at 11 days postinfection (hematoxylin and eosin staining) (A, B, and C) Overview of the thalamus (original magnification: ×200). (A) Control mice showing no degenerative changes. B (less affected animal) and C (more affected animal) illustrate infiltrating cells and spongiform-like lesions (characterized by vacuolation in neuronal cell bodies) and degenerative neurons with small densely stained nuclei or eosinophilic cytoplasm. (D) Normal hippocampus from control mice, with magnification of CA1 (F) and CA3 (G) hippocampus layers. (E) After infection, degenerative changes appeared mostly in CA1 (H) and CA3 (I) hippocampal layers; degenerated neurons exhibited picnotic nuclei and vacuolated cells were present in CA3 hippocampal layers (DG: Dentate Gyrus). (D and E) Magnification: ×40; F, G, H, and I: original magnification: ×200.