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. 2013 Mar 25;76(2):162–167. doi: 10.1016/j.diagmicrobio.2013.02.011

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Copyright © 2013 Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — The proportion of EV71 and CA16 in severe and mild HFMD cases. EV71 indicates enterovirus 71; CA16, coxsackievirus A16. Among the severe cases positive for EV71/CA16, 99 (98.0%) cases were positive for EV71, and only 2 were positive for CA16. On the other hand, in the mild cases positive for EV71/CA16, 413 (81%) cases were positives for EV71, and 99 (19%) were positive for CA16. The result indicates that EV71 is the major pathogen in HFMD patients, especially in severe cases.