Skip to main content
. 2020 Apr 3;18:55. doi: 10.1186/s12964-020-00536-7

Fig. 6.

Fig. 6

CP-17 reversed the TF-1(IDH2/R140Q) differentiation block. a IC50 value of intracellular D-2-HG inhibition by CP-17 treatment in TF-1(IDH2/R140Q) cells. b TF-1(WT) or TF-1(IDH2/R140Q) cells were induced with 50 ng/mL EPO to differentiate for 7 days in the presence of 0, 1 μM, and 3 μM of CP-17. After then cells were collected, and color change induced by hemoglobin γ expression was photographed. D-2-HG level and hemoglobin γ protein expression were detected with LC-MS and western blot respectively