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. 2020 Apr 3;20:108. doi: 10.1186/s12935-020-1157-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — ZFPM2-AS1 was transcriptionally activated by YY1. a YY1 binding motif and the related binding site for YY1 in ZFPM2-AS1 promoter were acquired via searching JASPAR. b, c qRT-PCR and western blot analyses of YY1 mRNA level upon YY1 elevation or suppression. d The expression of ZFPM2-AS1 in response to YY1 elevation or suppression was detected by qRT-PCR. e The binding relation between YY1 and ZFPM2-AS1 promoter was ensured by ChIP using anti-YY1. f, g The luciferase activity of wild ZFPM2-AS1 promoter (P1) in differently transfected groups was detected by luciferase reporter assay. *P < 0.05, **P < 0.01. NS: no significance