Table 1.
Baseline characteristics of elderly AMI patients
| Variable | NHR < 5.74 | NHR ≥ 5.74 | P | MHR < 0.67 | MHR ≥ 0.67 | P | LDL-C/HDL-C < 3.57 | LDL-C/HDL-C ≥ 3.57 | P |
|---|---|---|---|---|---|---|---|---|---|
| n = 249 | n = 279 | n = 367 | n = 161 | n = 439 | n = 89 | ||||
| Age, year | 72.54 ± 0.34 | 72.76 ± 0.32 | 0.555 | 72.35 ± 0.27 | 73.36 ± 0.42 | 0.048 | 72.60 ± 0.25 | 72.93 ± 0.56 | 0.754 |
| Gender (male), n (%) | 150 (60.24%) | 183 (65.59%) | 0.203 | 206 (56.13%) | 127 (78.89%) | < 0.001 | 271 (61.73%) | 62 (69.66%) | 0.157 |
| Smoking status, n (%) | 92 (36.95%) | 118 (42.29%) | 0.210 | 134 (36.51%) | 76 (47.20%) | 0.021 | 167 (38.04%) | 43 (48.31%) | 0.071 |
| Hypertension, n (%) | 144 (57.83%) | 169 (60.57%) | 0.522 | 215 (58.58%) | 98 (60.87%) | 0.623 | 267 (60.82%) | 46 (51.69%) | 0.110 |
| Prior CAD, n (%) | 40 (16.06%) | 30 (10.75%) | 0.072 | 50 (13.62%) | 20 (12.42%) | 0.708 | 60 (13.67%) | 10 (11.24%) | 0.537 |
| Diabetes, n (%) | 51 (20.48%) | 86 (30.82%) | 0.007 | 94 (25.61%) | 43 (26.71%) | 0.792 | 112 (25.51%) | 25 (28.09%) | 0.613 |
| CVD, n (%) | 33 (13.25%) | 39 (13.98%) | 0.808 | 51 (13.90%) | 21 (13.04%) | 0.793 | 59 (13.44%) | 13 (14.61%) | 0.770 |
| SBP on admission (mmHg) | 132.81 ± 1.50 | 128.10 ± 1.49 | 0.013 | 131.50 ± 1.31 | 127.65 ± 1.77 | 0.073 | 130.14 ± 1.15 | 131.25 ± 2.75 | 0.854 |
| DBP on admission (mmHg) | 75.65 ± 0.84 | 75.61 ± 0.94 | 0.927 | 76.31 ± 0.76 | 74.07 ± 1.14 | 0.042 | 75.69 ± 0.69 | 75.34 ± 1.63 | 0.733 |
| HR on admission (beats/min) | 74.56 ± 0.93 | 80.35 ± 0.96 | < 0.001 | 76.44 ± 0.80 | 80.31 ± 1.29 | 0.023 | 77.11 ± 0.74 | 80.13 ± 1.78 | 0.364 |
| Hospitalization day | 7.56 ± 0.36 | 8.99 ± 0.45 | 0.013 | 7.99 ± 0.31 | 9.06 ± 0.66 | 0.466 | 8.08 ± 0.31 | 9.47 ± 0.85 | 0.290 |
| Diagnosis, n (%) | |||||||||
| STEMI | 98 (39.36%) | 170 (60.93%) | < 0.001 | 181 (49.32%) | 87 (54.04%) | 0.318 | 216 (49.20%) | 52 (58.43%) | 0.112 |
| NSTEMI | 151 (60.64%) | 109 (39.07%) | < 0.001 | 186 (50.68%) | 74 (45.96%) | 0.318 | 223 (50.80%) | 37 (41.57%) | 0.112 |
| Killip class, III-IV, n (%) | 41 (16.47%) | 60 (21.51%) | 0.142 | 61 (16.62%) | 40 (24.84%) | 0.027 | 81 (18.45%) | 20 (22.47%) | 0.379 |
| LVEF, % | 53.72 ± 0.78 | 50.45 ± 0.75 | 0.001 | 52.85 ± 0.61 | 50.02 ± 1.11 | 0.042 | 51.93 ± 0.61 | 52.27 ± 1.23 | 0.464 |
| Creatinine (μmol/L) | 84.54 ± 1.70 | 95.13 ± 2.13 | < 0.001 | 87.59 ± 1.71 | 95.94 ± 2.34 | < 0.001 | 88.89 ± 1.47 | 96.29 ± 4.01 | 0.169 |
| AST (u/L) | 56.61 ± 4.44 | 119.89 ± 7.63 | < 0.001 | 92.17 ± 6.09 | 85.22 ± 7.04 | 0.373 | 89.69 ± 4.97 | 91.84 ± 13.88 | 0.584 |
| ALT (u/L) | 29.47 ± 1.72 | 43.56 ± 2.76 | < 0.001 | 34.27 ± 1.72 | 42.94 ± 3.91 | 0.004 | 36.85 ± 1.94 | 37.22 ± 3.15 | 0.904 |
| NT-proBNP (pg/mL) | 4815.92 ± 560.61 | 5601.26 ± 538.24 | 0.057 | 4934.39 ± 467.27 | 5906.79 ± 697.26 | 0.008 | 5204.51 ± 431.33 | 5316.10 ± 888.55 | 0.287 |
| CTnI (pg/mL) | 9435.84 ± 911.21 | 20,906.32 ± 1202.02 | < 0.001 | 14,994.50 ± 975.91 | 16,642.27 ± 1426.50 | 0.094 | 15,550.19 ± 880.71 | 15,234.31 ± 2005.53 | 0.918 |
| HDL-C (mmol/L) | 1.30 ± 0.04 | 0.98 ± 0.02 | < 0.001 | 1.24 ± 0.03 | 0.89 ± 0.02 | < 0.001 | 1.19 ± 0.02 | 0.84 ± 0.02 | < 0.001 |
| LDL-C (mmol/L) | 2.55 ± 0.06 | 2.66 ± 0.06 | 0.312 | 2.69 ± 0.05 | 2.43 ± 0.07 | 0.004 | 2.41 ± 0.04 | 3.62 ± 0.10 | < 0.001 |
| Total triglyceride (mmol/L) | 1.36 ± 0.07 | 1.42 ± 0.07 | 0.113 | 1.33 ± 0.06 | 1.53 ± 0.10 | 0.012 | 1.36 ± 0.06 | 1.55 ± 0.09 | 0.002 |
| Total cholesterol (mmol/L) | 4.10 ± 0.07 | 4.14 ± 0.07 | 0.693 | 4.25 ± 0.06 | 3.84 ± 0.08 | < 0.001 | 3.95 ± 0.05 | 4.98 ± 0.12 | < 0.001 |
| WBC count (109/L) | 6.72 ± 0.13 | 11.10 ± 0.21 | < 0.001 | 8.30 ± 0.17 | 10.72 ± 0.31 | < 0.001 | 8.97 ± 0.17 | 9.38 ± 0.38 | 0.780 |
| Platelet count (109/L) | 191.70 ± 3.82 | 212.31 ± 4.01 | < 0.001 | 200.59 ± 3.32 | 207.16 ± 5.27 | 0.379 | 200.23 ± 3.06 | 214.22 ± 7.08 | 0.372 |
| Neutrophil count (109/L) | 4.56 ± 0.11 | 9.19 ± 0.21 | < 0.001 | 6.36 ± 0.17 | 8.47 ± 0.33 | < 0.001 | 6.98 ± 0.18 | 7.14 ± 0.37 | 0.357 |
| Lymphocyte count (109/L) | 1.40 ± 0.04 | 1.37 ± 0.04 | 0.142 | 1.32 ± 0.03 | 1.53 ± 0.06 | 0.002 | 1.37 ± 0.03 | 1.47 ± 0.08 | 0.809 |
| Monocyte count (109/L) | 0.45 ± 0.01 | 0.65 ± 0.02 | < 0.001 | 0.43 ± 0.01 | 0.84 ± 0.02 | < 0.001 | 0.55 ± 0.01 | 0.57 ± 0.03 | 0.145 |
| Hemoglobin (mg/dL) | 126.65 ± 1.19 | 125.87 ± 1.10 | 0.536 | 126.88 ± 0.95 | 124.78 ± 1.53 | 0.297 | 126.02 ± 0.86 | 127.34 ± 2.26 | 0.922 |
| Medications in hospital, n (%) | |||||||||
| Antiplatelet therapy | 243 (97.59%) | 271 (97.13%) | 0.744 | 361 (98.37%) | 153 (95.03%) | 0.051 | 427 (97.27%) | 87 (97.75%) | 0.003 |
| Beta-blocker | 182 (73.09%) | 198 (70.97%) | 0.587 | 271 (73.84%) | 109 (67.70%) | < 0.001 | 317 (72.21%) | 63 (70.79%) | 0.237 |
| ACEI/ARB | 191 (76.71%) | 187 (67.03%) | 0.014 | 271 (73.84%) | 107 (66.46%) | 0.083 | 318 (72.44%) | 60 (67.42%) | 0.596 |
| Statin | 247 (99.20%) | 275 (98.57%) | 0.915 | 364 (99.18%) | 158 (98.14%) | 0.297 | 434 (98.86%) | 88 (98.88%) | 0.002 |
| Long-term clinical events, n (%) | |||||||||
| Long-term mortality | 17 (6.83%) | 59 (21.15%) | < 0.001 | 40 (10.90%) | 36 (22.36%) | 0.001 | 50 (11.39%) | 26 (29.21%) | < 0.001 |
| Long-term RMI | 10 (4.02%) | 31 (11.11%) | 0.002 | 22 (5.99%) | 19 (11.80%) | 0.022 | 29 (6.61%) | 12 (13.48%) | 0.010 |
AMI acute myocardial infarction, NHR neutrophil to high-density lipoprotein cholesterol ratio, MHR monocyte to high-density lipoprotein cholesterol ratio, LDL-C/HDL-C low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, CAD coronary artery disease, CVD cerebrovascular diseases, SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, STEMI ST-segment elevation myocardial infarction, NSTEMI non-ST-elevation myocardial infarction, LVEF left ventricular ejection fraction, AST aspartate aminotransferase, ALT alanine aminotransferase, NT-proBNP N-terminal pro-brain natriuretic peptide, CTnI cardiac troponin I, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, WBC white blood cell, ACEI/ARB angiotensin-converting enzyme inhibitor/ angiotensin II receptor blocker, RMI recurrent myocardial infarction
Data presented are mean ± SEM or n(%)