Fig. 1.

Effects of orally adminstered emodin on lethal HSV challenge model. Emodin at 3.3, 6.7 and 11.3 g/kg/day was orally administered 24 h post viral infection with 100 LD₅₀ of HSV. (A) Survival curves for BALB/c mice after HSV-1 infection with emodin treatment. (B) Survival curves for BALB/c mice after HSV-2 infection with emodin treatment. (C) Mean time death (MTD) of BALB/c mice from different experimental groups. *The 6.7 g/kg/day emodin groups showed prolonged MTD compared to those in 3.3 g/kg/day and 11.3 g/kg/day groups (p < 0.01). **The 6.7 g/kg/day emodin group showed favorable survival rates in both HSV subtype infected mice and longer MTD in HSV-1 infected mice compared to ACV treatment group (p < 0.01).