Table 1.
The antiviral effect of emodin and ACV on the replication of HSV-1 and HSV-2.
| Compound | Dosage (μg/ml) | Viral titera (log10TCID50)/antiviral index |
|
|---|---|---|---|
| HSV-1 | HSV-2 | ||
| Emodin | 5 | 5.8 ± 0.24 (1.03) | 6.0 ± 0.27 (1.00) |
| 15 | 5.4 ± 0.25 (1.11) | 4.4 ± 0.21 (1.50) | |
| 25 | 4.1 ± 0.18 (1.46) | 3.1 ± 0.17 (1.94) | |
| 50 | 2.9 ± 0.21 (2.07) | 1.7 ± 0.24 (3.53) | |
| 100 | 1.9 ± 0.21 (3.21) | 1.1 ± 0.14 (5.35) | |
| 200 | 1.1 ± 0.09 (5.55) | 0.6 ± 0.11 (10.0) | |
| 300 | 0.7 ± 0.11 (8.71) | 0.2 ± 0.14 (30.0) | |
| Acyclovir | 5 | 5.7 ± 0.25 (1.05) | 5.8 ± 0.21 (1.03) |
| 15 | 5.6 ± 0.21 (1.07) | 5.6 ± 0.24 (1.07) | |
| 25 | 4.5 ± 0.20 (1.20) | 3.6 ± 0.21 (1.67) | |
| 50 | 2.5 ± 0.22 (2.40) | 2.1 ± 0.23 (2.86) | |
| Control | – | 6.1 ± 0.31 | 6.0 ± 0.34 |
a
Viral titer represent geometric mean ± SD of three independent experiments.