Table 1.

Prothymosin Alpha Fragments with Distinct Activities

ProTα Fragment	Type of Activity	Reported in:
ProTα(1–28), referred to as “Tα1”	Immunomodulatory; DC activation; anticancer; antiviral; antifungal; vaccine enhancement	Camerini and Garaci (2015)
ProTα(1–35), referred to as “Tα11”	Antifungal	Hannappel and Huff (2003)
ProTα(49–78) (P30) ProTα(52–60) (P9)	Neuroprotective	Halder, Sugimoto, Matsunaga, and Ueda (2013)
ProTα(50–89), referred to as “Mosoian domain”	Anti-HIV-1	Mosoian et al. (2010)
ProTα variants (p7 [proTα(32–49)] and isoB [proTα(32–41), proTα(51–55), proTα(56–61), proTα(65–71)])	Anti-HIV-1	Teixeira et al. (2015)
ProTα(100–109), referred to as “Skopelitian domain”	Immunomodulatory; anticancer; DC maturation; enhancement of phagocytosis, respiratory burst, and cytotoxicity of human neutrophils	Skopeliti et al. (2009), Voutsas et al. (2013), Ioannou et al. (2013), and Samara, Ioannou, et al. (2013)
ProTα(1–100)	Cardioprotective	Cannavo et al. (2013)