. 2007 Feb 12;61(4):229–234. doi: 10.1016/j.biopha.2007.01.003

Table 2.

Effect of lycorine on survival days of SCID mice inoculated with HL-60 cells

Groups	No. of mice	Dosage and route (i.p.)	Survival days		ILS (%)	T/C (%)
Groups	No. of mice	Dosage and route (i.p.)	Mean ± SD	Range	ILS (%)	T/C (%)
Control	5	Normal saline	41.6 ± 7.3	34–49
Lycorine	5	5 mg/kg/day	54.2 ± 13.8*^,#	38–71	30.0	130
Lycorine	5	10 mg/kg/day	55.8 ± 10.2**^,##	39–64	34.0	134
Ara-C	5	20 mg/kg/day	42.8 ± 9.8	30–52	3.0	103

Female BALB/c SCID mice (3–5 weeks old) were injected i.v. with 5 × 10⁶ HL-60 cells. Treatment of lycorine or Ara-C was started 1 day after the HL-60 cell injection. T/C, treated vs. control; ILS, increased life span. *P = 0.024, compared with control group; ^#P = 0.011, compared with the Ara-C treated group; **P = 0.007, compared with control group; ^##P = 0.002, compared with the Ara-C treated group.