Table 3.
Effect of lycorine on weight of SCID mice inoculated with HL-60 cells
| Groups | No. of mice | Dosage and route (i.p.) | Weight of SCID mice (Mean ± SD) (g) |
|||
|---|---|---|---|---|---|---|
| d 0 | d 14 | d 21 | d 28 | |||
| Control | 5 | Normal saline | 16.2 ± 2.8 | 16.7 ± 1.8 | 16.7 ± 0.7 | 17.8 ± 1.7 |
| Lycorine | 5 | 5 mg/kg/day | 17.8 ± 1.5 | 16.6 ± 0.7 | 17.2 ± 0.3 | 17.7 ± 1.7 |
| Lycorine | 5 | 10 mg/kg/day | 17.1 ± 0.8 | 16.5 ± 1.3 | 17.0 ± 0.8 | 17.1 ± 1.8 |
| Ara-C | 5 | 20 mg/kg/day | 15.5 ± 2.2 | 15.1 ± 1.8 | 15.0 ± 1.8 | 14.7 ± 2.4 |
Female BALB/c SCID mice (3–5 weeks old) were injected i.v. with 5 × 106 HL-60 cells. The mice were weighed at day 0, day 14, day 21 and day 28.