Table 5.
Multivariate Cox models of risk factors for mortality attributable to pneumonia by day 60 after bronchoalveolar lavage fluid sampling.
| Variable | Univariate |
Multivariate |
||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95%CI) | P value | |
| Sex (male vs. female) | 0.87 (0.46-1.63) | NS | ||
| Age ≥65 years | 1.30 (0.46-3.64) | NS | ||
| Donor type | ||||
| Umbilical cord blood | 3.07 (1.33-7.10) | 0.009 | NS | |
| Unrelated | 1.24 (0.51-3.06) | NS | ||
| Haploidentical | 0.99 (0.37-2.65) | NS | ||
| HLA-identical sibling | 1 | |||
| CMV serostatus | ||||
| D+/R+ | 0.48 (0.19-1.20) | NS | ||
| D-/R+ | 0.55 (0.21-1.43) | NS | ||
| D+/R- | 0.45 (0.11-1.78) | NS | ||
| D-/R- | 1 | |||
| ATG as a part of conditioning | 2.15 (1.15-4.03) | 0.02 | NS | |
| aGvHD grades III-IVa | 1.95 (0.95-3.99) | 0.068 | NS | |
| cGvHD | 1.02 (0.49-2.15) | NS | ||
| Etiology of pneumonia | ||||
| Non-infectious | 1.63 (0.55-4.88) | NS | ||
| Viral | 0.93 (0.32-2.67) | NS | ||
| Fungal | 0.66 (0.19-2.28) | NS | ||
| Mixed infection | 0.67 (0.22-1.99) | NS | ||
| Bacterial | 1 | |||
| Presence of CMV DNA in BAL vs. absence | 1.70 (0.91-3.18) | 0.10 | ||
| CMV DNA load in BAL (IU/mL) | ||||
| >500 IU/mL | 2.31 (1.24-4.30) | 0.009 | 2.21 (1.13-4.32) | 0.02 |
| <500 IU/mL | 0.68 (0.24-1.97) | NS | ||
| No CMV | 1 | 1 | ||
| High (7-12) | 3.71 (1.35-10.22) | 0.003 | NS | |
| Moderate (3-6) | 3.39 (1.39-8.30) | 0.008 | NS | |
| Low (0–2) | 1 | |||
| Treatment with corticosteroids | 2.80 (1-39-5.62) | 0.004 | 2.13 (1.04-4.33) | 0.04 |
| Absolute lymphocyte countb< 0.7 × 109/L | 4.88 (2.05-11.63) | <0.001 | 4.16 (1.72-10.04) | 0.002 |
aGvHD, acute graft versus host disease; ATG, anti-thymocyte globulin; BAL, bronchoalveolar lavage fluid; cGvHD, chronic graft versus host disease; CMV, cytomegalovirus; D, donor; NS, not significant; R, recipient.
a
According to [30].
b
The cut-off was established by ROC analysis (not shown).